What is another method/reagent for achieving the same overall transformation from Olefin 9 to ketone 10? How does this method compare to the one used?
Another method is to use potassium permanganate instead of osmium tetroxide (OsO4). Potassium permanganate is a very powerful oxidizing agent. The mechanism for potassium permanganate is very similar to that of osmium tetroxide. The general reaction scheme is shown below:(1)
Kreatopia (Minced Meat Pie)Ingredients: 3lb 6oz minced meat (lamb/beef) 2lbs 4oz onions 5 tablespoons butter 10 eggs 1 cup milk 2 cups semolina salt and pepper cinnamon 2lbs 4oz phyllo dough Scroll down for the directions! |
Potassium permanganate is not as effective as osmium tetroxide because it is too powerful for our reaction. However, there are many benefits of potassium permanganate. It is inexpensive, water-soluble, and is soluble in non-polar solvents (ie dichloromethane).1 In addition, the product can be easily isolated because potassium permanganate can be removed by filtration and flash evaporation (evaporation that separates the product based on boiling points) (2,3)
Works Cited
1. Lee, Donald G., Maria Ribagorda, and Javier Adrio. "Potassium Permanganate." Encyclopedia of Reagents for Organic Synthesis. 2007. Web. 7 Apr. 2010. <http://www.mrw.interscience.wiley.com/eros/articles/rp244/sect0-fs.html>.
2. Lee, Donald G. "Potassium Permanganate–Copper(II) Sulfate." Encyclopedia of Reagents for Organic Synthesis. 2001. Web. 7 Apr. 2010. <http://www.mrw.interscience.wiley.com/eros/articles/rp245/sect0-fs.html>.
3. "Flash Distillation." Rensselaer Polytechnic Institute. Web. 07 Apr. 2010. <http://www.rpi.edu/dept/chem-eng/Biotech- Environ/Environmental/desal/flash.html>.
1. Heat half of the butter in a pan and saute one onion. 2. Add the minced meat, salt and pepper, cinnamon, and two cups of water. Cook until the water is gone. 3. Cut the remaining onions into quarters, and in a separate pot, boil them in broth or in water containing the meat bones. 4. When the onions are boiled, take them out and puree them. Strain the broth and keep two cups of it. 5. Prepare a cream with the milk, the semolina, and broth. Put this in the fridge for an hour. 6. Add the pureed onions, eggs, the remaining butter, cinnamon, salt and pepper to the cooled cream. 7. Brush the bottom and sides of a pan with butter and line it with half the sheets of phyllo dough. 8. Spread the minced meat evenly and pour the cream mixture over it. Cover with the remaining sheets of phyllo pastry and brush with butter. 9. Bake the pie 375˚F until the top starts to turn golden brown (~30 min) For more great greek recipes visit: Greek-Recipe.com |
